Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. In regards to malaria what is chloroquine resistance Side effects of taking too much plaquenil Plaquenil and stomach problems The mechanism for hyperpigmentation is poorly understood. Risk factors appear to be linked to bruising, corticosteroid use, oral anticoagulants, antiplatelet agents, antiphospholipid syndrome and skin trauma.1 Histology usually shows superficial dermal deposition of brown-pigmented granules of iron or melanin, or both. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Lichen planus pigmentosus A short review. patterns of LPP were later considered as a single entity in view of a common clinical picture of mostly asymptomatic pigmentation with lichenoid histology. Epidemiology. argyria, hydroxychloroquine, chloroquine, amiodarone, and minocycline. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine pigmentation histology Hydroxychloroquine Side Effects Common, Severe, Long Term., Hydroxychloroquine MedlinePlus Drug Information Chloroquine and cancer stem cellsDosage of plaquenil Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Hydroxychloroquine-Induced Pigmentation in Patients With.. Lichen planus pigmentosus A short review Mathews I.. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Hydroxychloroquine-Induced Hyperpigmentation. From the Departments of *Rheumatology and †Dermatology, Walter Reed National Military Medical Center; and ‡Uniformed Services University of the Health Sciences, Bethesda, MD. No financial support was received for this study. The authors declare no conflict of interest. Oct 30, 2008 Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4–5 years. She presented with a mottled, reticulated macular gray pigmentation involving the upper back and shoulders. Case 2 had a history of systemic lupus erythematosus and rheumatoid arthritis. We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female case 1 and a 78-year-old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4-5 years.