Chloroquine retinopathy after drug cessation

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  1. dlont Moderator

    Chloroquine retinopathy after drug cessation


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Jan 05, 2020 In general, hydroxychloroquine and chloroquine retinopathy are not reversible, and even following drug cessation, cellular damage appears to continue for a certain period of time. However, the earlier the retinopathy is recognized, the greater the chance of visual preservation. Keratopathy has been reported to be fully reversible. References Long-Term Course of Chloroquine Retinopathy after Cessation of Medication - ScienceDirect JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article Chloroquine retinopathy is an important complication that may appear even years after cessation of the drug, presenting with impaired visual acuity, central vision loss and progressive damage that could result in irreversible blindness. A detailed patient history that confirms chloroquine use is essential, while advanced ophthalmologic methods must be employed to assess the status of the retina.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine retinopathy after drug cessation

    Common Medications That May Be Toxic to the Retina, Long-Term Course of Chloroquine Retinopathy after Cessation.

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  4. Clearance of the HCQ from blood and urine can take months to years after drug cessation and visual function may continue to deteriorate slowly even after the therapy was stopped. Hydroxychloroquine Retinopathy. Chloroquine retinopathy was described for the first time in the early ’60s.

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    Oct 01, 2018 Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body 2. There are no adequate and well-controlled studies evaluating the safety and efficacy of Chloroquine in pregnant women. Delayed-onset chloroquine retinopathy was diagnosed in a patient seven years after cessation of treatment by a total dose of 730 g of chloroquine for rheumatoid arthritis. Visual functions. After the cessation of chloroquine treatment, early subtle macular changes can revert to normal. Although far advanced cases may progress despite discontinuation of the drug, most patients remain stable with long-term follow-up. 41,42 Chloroquine, however, is very slowly excreted from the body.

     
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    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Calcium Pyrophosphate Deposition CPPD Disease Management Hypercalcemia - Cleveland Clinic
     
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