Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Hydroxychloroquine pka Rheumatoid drug plaquenil Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. We compare the side effects and drug effectiveness of Plaquenil and Methotrexate. The study is created by eHealthMe based on reports of 385,604 people who take Plaquenil and Methotrexate, and is updated regularly. eHealthMe has been monitoring drugs since 2008. Our original studies are referenced on 600+ peer-reviewed medical publications. This is a really good article. I am on Plaquenil and Methotrexate. We tried Enbrel for a year, then had to switch to Remicade. Still not working well, we have increased the dosage twice. I am on Prednisone 5mg just as a temporary measure until I go back next week. It is time to move on, but I couldn’t decide between Rituxin, Acterma, or Orencia. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. How to switch from plaquenil to methotrexate Side effects plaquenil/methotrexate. rheumatoid, Plaquenil vs. Methotrexate side effect and effectiveness. Can you take zantac with plaquenilChloroquine syrup indiaHow long does plaquenil take to work for ra Apr 21, 2017 I had to stop methotrexate about 7 months ago for my RA, due to bad side effects after using it successfully for 10 years. As an alternative, my rheumy put me on HCQS, also known as plaquenil, along with. Plaquenil aka HCQS – Anyone on this getting severe diarrhea.. Switching Medications Without Waiting too Long RA. Methotrexate and its benefit for Sjögren’s patients. Jun 09, 2012 I've been on methotrexate for just over a year for RA. I have also tried hydroxychloroquine and sulfazalazine both of which caused tinnitus so had to come off them. My consultant has now put my methotrexate up to 25mg to see if my symptoms improve. Learn when your doctor might switch you to one of these drugs, and how to make the change. like methotrexate, sulfasalazine, hydroxychloroquine, or leflunomide. May 07, 2017 Plaquenil inhibits disease progression. That means, it keeps it from getting worse and progressing faster. We generally will not be able to tell it is doing anything unless we go off it and see how bad things can get -- which of course is not a recommend act! And, Plaquenil takes 2-3 months to build up in your system.