My worst symptoms so far have been raynauds, fatigue, telangiectasias , heart burn, and digital ulcers. I'm fortunate that my lungs have been unaffected up to this point but I'm worried that contracting the virus could cause fibrosis in the lungs and lead to ILD and PAH. Hydroxychloroquine discontinued side effects Does plaquenil reduce inflammation Hydroxychloroquine and naproxen Calcium phosphate transfection chloroquine Nov 25, 2019 Usual Adult Dose for Rheumatoid Arthritis. -Initial dose 400 to 600 mg 310 to 465 mg base orally once a day to optimum response usually 4 to 12 weeks -Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; In addition, those with limited scleroderma tend to have telangiectasias, a collection of dilated blood vessels under the skin 85% of patients; digestive problems involving the esophagus 80%; and calcinosis 50%, often called CREST syndrome calcinosis, Raynaud's, esophageal disease, sclerodactyly and telangiectasia. The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. If you google you will find details of compounding pharmacies. Anybody have any knowledge about this that they can share? I've been trying to do some research but haven't come up with any solid answers. Plaquenil crest syndrome CREST syndrome symptoms, treatments & forums PatientsLikeMe, Scleroderma Guide Causes, Symptoms and Treatment Options Does plaquenil cause heat intolerancePlaquenil hyponatremiaChloroquine inhibits autophagic flux by decreasing autophagosome lysosome fusion According to my opinion, Raynaud's phenomenon is a part of CREST syndrome of systemic sclerosis. In case that is troubling you, the best treatment that I have found very successful is the use of crushed Sorbitrate tablets in coconut oil and apply them to massage over th. Common "Crest Syndrome" queries answered by top doctors iCliniq. Discontinued Plaquenil.other options?. COVID-19 and scleroderma scleroderma. Carol F CREST Syndrome I feel so alone right now and it would be nice to talk with someone who understands what I am going through. For the last two years my hands and feet have been going numb. At first I really did not think much of it since I had had a three herniated disc cervical injury and thought it could have been from that. My wife has recently been diagnosed with CREST/scleroderma. Can anything be said about the overall life expectancy of people with this diagnosis? Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.