Chloroquine mechanism of action pdf

Discussion in 'Canada Pharmaceuticals Online' started by SergeZ, 18-Mar-2020.

  1. pollpoll Moderator

    Chloroquine mechanism of action pdf


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Resistance phenomena to antimalarial drugs, particularly to chloroquine but even with the most recent ones, urges the development of new molecules. Important efforts have been realized to understand the molecular mechanisms for drug action and resistance and to find new antimalarial compounds. In this Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action pdf

    Chloroquine mechanism of drug action and resistance in., Chloroquine in Cancer Therapy A Double-Edged Sword of.

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  7. Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against. Plasmodium. is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.

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    Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Chloroquine- resistant parasites accumulate less chloroquine in the food vacuole than do sensitive parasites Fitch, 1970 and one assumption is that chloroquine resistance is not based on the mode of action of the drug but on the access of the drug to the parasite food vacuole. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base. The adult chloroquine dose is 300 mg base weekly or in some countries 100 mg base daily.

     
  8. Stan_Ly User

    JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)A, Bluish-green pigmentation on the legs in a patient with systemic lupus erythematosus without lupus lesions at the time of the skin biopsy. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine-related skin discoloration CMAJ Hydroxychloroquine-induced Hyperpigmentation of the Skin Skin pigmentation induced by meropenem and levofloxacin.
     
  9. Okean11 Well-Known Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. New Plaquenil Guidelines Hydroxychloroquine Oral Route Precautions - Mayo Clinic Hydroxychloroquine - Side Effects, Dosage, Interactions.
     
  10. Qsman Guest

    Lupus and Cancer Johns Hopkins Lupus Center In fact, 85% of lung cancer is caused by tobacco. It is very important that people with lupus do not smoke. Smoking not only increases the chance of developing lung cancer, it also ups the risk for cardiovascular disease which is also markedly increased in people with lupus, and prevents lupus drugs like Plaquenil from working properly.

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.