What is putative chloroquine transporter

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    What is putative chloroquine transporter


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Analysis of the D. dadantii genome revealed the presence of a putative ABC transporter, YbiT, which may be important in intermicrobial competition. The protein YbiT showed identity with those of other Gram-negative bacteria including E. coli 87%, Vibrio cholerae N16961 74%, P. aeruginosa PA01 72%, and Neisseria meningitidis MD58 63%. Start studying Pharmacology 2 - Antimalarials. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Why chloroquine is used. Identical and fraternal twins have also been reported to have itched, nevertheless, this was much like kids of the same parents who don’t all itch following chloroquine administration. There was nonetheless a distinction within the depth of itch after utilizing chloroquine in malaria therapy.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    What is putative chloroquine transporter

    What does chloroquine treat – Kailash Store, Pharmacology 2 - Antimalarials Flashcards Quizlet

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  4. The putative transporter PfCRT was identified through the analysis of a genetic cross between a chloroquine-sensitiveCQSandaCQRclone,whichmappedresistance to the gene pfcrt 16,17. The 45-kDa PfCRT protein con-tainstenpredictedtransmembranedomainsandislocated on the membrane of the digestive vacuole – an acidic,

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    May regulate endogenous transporter. UniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents. UniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Sep 15, 2001 In P. falciparum the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Rapid diagnostic assays for PfCRT mutations are already employed as surveillance tools for drug resistance.

     
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    Chloroquine C18H26ClN3 ChemSpider An aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine.

    A New Synthesis of Chloroquine Journal of the American.