One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Visual field test for hydroxychloroquine Plaquenil photosensitivity rash Malarial chloroquine resistance Photodegradation of chloroquine phosphate Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus. Importance Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Drug-induced hyperpigmentation is a relatively frequent reason for consultation, especially in polypharmacy patients. The sample may have been biased as many patients receiving treatments frequently associated with drug-induced hyperpigmentation, such as antineoplastic drugs, are diagnosed and treated by other specialties, such as oncologists. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil induced hyperpigmentation Woman in grey hydroxychloroquine-induced hyperpigmentation, Hydroxychloroquine-Induced Pigmentation in Patients With. Is chloroquine injection safe in early pregnancyPlaquenil macular edemaHow plaquenil helps lupus ph levelsDoes plaquenil lead to kidney failureVision loss from plaquenil Cutaneous pigmented lesions were found in 21 cases 51%, mucous pigmentation in 5 cases 12% and nail pigmentation in 1 case 2.5%. In 12 of 41 29% of the hydroxychloroquine users, we conclude a hydroxychloroquine-induced pigmentation. Hydroxychloroquine-induced hyperpigmentation in systemic.. Drug-Induced Hyperpigmentation Review and Case Series American Board.. Drug-induced nail disease DermNet NZ. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. There was no pigmentation at other body sites. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti-inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals.