Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. What is plaquenil use for Hydroxychloroquine nutrient interactions michigan Chloroquine and brain cancer Higher doses can sometimes be used, but only in adults and not for all cases. Some people tolerate this medication much better than other people, so it is important that individuals who are considering taking hydroxychloroquine talk with their doctor about the lowest necessary dose to reduce or eliminate their symptoms. The Hydroxychloroquine Dosing Calculator calculates appropriate daily dose of hydroxychloroquine. SARCOIDOSIS TREATMENT GUIDELINES INTRODUCTION Sarcoidosis is a chronic inflammatory granulomatous dis-ease that primarily affects the lungs, although multi-organ involvement is common. The etiology of sarcoidosis is not clear; however, genetic and environmental factors probably play a role in the development and expression of the disease. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil dosing guidelines Plaquenil hydroxychloroquine sulfate dose, indications., Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc Adverse effect of hydroxychloroquinePlaquenil prototypeHla-dr4 rheumatoid arthritis and hydroxychloroquinePlaquenil 400 mg bidChloroquine in hepatic dysfunction The ideal weight dosing guidelines were based on a set of articles written about scientific experiments done on rats and “a few scrawny monkeys” nearly half a century ago, according to Michael. Despite Plaquenil dosing recommendations, retinal toxicity.. SARCOIDOSIS TREATMENT GUIDELINES. New Plaquenil Guidelines -. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs. There was a dose response, such that those receiving doses greater that 5 mg / kg had the greatest risk of retinal toxicity. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. In a small percentage of patients, side effects may require temporary reduction of the initial dosage. Maintenance adult dosage When a good response is obtained, the dosage may be reduced by 50 percent and continued at a maintenance level of 200 mg to 400 mg 155 to 310 mg base daily, administered as a single daily dose or in two divided doses.