Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil and thinning outer nuclear layer of retina Plaquenil pictures generic Dmard therapy hydroxychloroquine Falciparum gb4 chloroquine Metoprolol/Selected CYP2D6 Inhibitors Interactions. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil metabolism Hydroxychloroquine Dosage Guide with Precautions -, Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Plaquenil surgery healingPlaquenil eye screening guidelinesChloroquine dose for malaria prophylaxisWhat to expect when stop taking plaquenilHydroxychloroquine sulfate monitor Antimalarials and effects on lipid metabolism. There is increasing evidence demonstrating the beneficial impact of antimalarial agents on lipid metabolism besides glycemic control Table 2. In rat hepatocytes, CQ was shown to be an effective inhibitor of cholesterol synthesis Beynen et al. 1981. A favorable effect of hydroxychloroquine on glucose and.. Plaquenil hydroxychloroquine sulfate dosing, indications.. Plaquenil hydroxychloroquine sulfate dose, indications.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine is available in generic forms and under the brand names of Plaquenil in tablets of 200 mg. The usual dose is 400 mg daily in one or two divided doses. Common side effects include headaches, dizziness, gastrointestinal upset and rash. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication.