Low-dose hydroxychloroquine in treatment of porphyria

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  1. Intildzillina Moderator

    Low-dose hydroxychloroquine in treatment of porphyria


    These disorders are usually inherited, meaning they are caused by abnormalities in genes passed from parents to children. When a person has a porphyria, cells fail to change body chemicals called porphyrins and porphyrin precursors into heme, the substance that gives blood its red color.

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    Dec 20, 2019 Porphyria cutanea tarda PCT is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase UROD is deficient. Approximately 80% of all cases of porphyria cutanea tarda are acquired; 20% are familial, although the ratio may vary among different geographic regi. Methods. We analyzed data from 48 consecutive patients with well-documented PCT to characterize susceptibility factors; patients were treated with phlebotomy 450 mL, every 2 weeks until they had serum ferritin levels of 20 ng/mL or low-dose hydroxychloroquine 100 mg orally, twice weekly, until at least 1 month after they had normal plasma levels of porphyrin. The recommended dosages are 100 mg twice a week for hydroxychloroquine or 125 mg twice a week for chloroquine. Such a low dose schedule is equally effective as phlebotomy and easier to take with less treatment cost involved.

    Bone marrow is the soft, spongelike tissue inside the bones; it makes stem cells that develop into one of the three types of blood cells—red blood cells, white blood cells, and platelets. The body makes heme mainly in the bone marrow and liver.

    Low-dose hydroxychloroquine in treatment of porphyria

    Low-dose hydroxychloroquine is as effective as phlebotomy in treatment., Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in.

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  5. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda. Clin Gastroenterol Hepatol. 2012. 450 mL, every 2 weeks until they had serum ferritin levels of 20 ng/mL or low-dose hydroxychloroquine 100 mg orally, twice weekly, until at least 1 month after they had normal plasma levels of.

    • Low-dose hydroxychloroquine is as effective as phlebotomy..
    • Porphyria Cutanea Tarda PCT - American Porphyria Foundation.
    • Porphyria NIDDK.

    Dosing recommendations in porphyria cutanea tarda. In the treatment of porphyria cutanea tarda, hydroxychloroquine 100 mg should be prescribed twice weekly for one month, then 200 mg/day until plasma porphyrin levels are normal for at least a month. Low-dose hydroxychloroquine is generally as effective as phlebotomy for treatment of PCT, but longer studies are needed to compare relapse rates. Singal AK, Kormos-Hallberg C, Lee C, et al. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda. Oct 30, 2019 Porphyria cutanea tarda. Data from a randomized, nonblinded pilot study support the use of hydroxychloroquine in the treatment of porphyria cutanea tarda Singal 2012. Primary Sjögren syndrome extraglandular manifestations

     
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    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Plaquenil Plaquenil - how long for side effects to subside? Hydroxychloroquine Side Effects Common, Severe, Long Term.
     
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    Anti-neutrophil Cytoplasmic Antibody. - PubMed Central PMC His medications at presentation included monthly 25 g intravenous immunoglobulins IVIG for the last 12 years that resulted in amelioration of his recurrent sinusitis, hydroxychloroquine 200 mg and omeprazole 20 mg twice a day, atorvastatin 10 mg and irbesartan 150 mg once a day, eszopiclone 0.75 mg and temazepam 30 mg every night.

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