People who have this virus and take certain disease-modifying medications for MS may be at risk for a rare, yet serious, disease. The disease is called progressive multifocal leukoencephalopathy (PML). Plaquenil and bone health Patient teaching when taking hydroxychloroquine Hydroxychloroquine sulphate tablets ip Nov. 16, 2004 -- For people with rheumatoid arthritis, methotrexate is the treatment of choice in reducing pain and inflammation. But there's evidence the drug can activate a virus that can increase the risk of lymphoma and similar cancers in some patients. The study appears in this month's issue. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Progressive multifocal leukoencephalopathy PML is an opportunistic infection of the central nervous system CNS, caused by the polyoma virus JC virus JCV and characterized by focal demyelination. 1,2 The virus has worldwide distribution, with a seroprevalence of 39% to 69% among adults. 3-6 Primary JCV infection usually occurs. In MS, it is the loss of myelin that damages nerve function. It results when JC virus infects oligodendrocytes, cells that insulate nerve cells with myelin. Jc virus and plaquenil Progressive Multifocal Leukoencephalopathy and Systemic Lupus., Hydroxychloroquine Plaquenil Side Effects & Dosage for. How much is chloroquine in the usPlaquenil pregnanChloroquine mechanism of resistance The JC virus John Cunningham virus is the infection that leads to PML. This virus behaves much like other common viral infections such as herpes and the chicken pox. When you get the chicken pox the virus never leaves your body, and later in life it may flare up again and cause a condition called shingles. Understanding PML and the JC Virus -. PML/JCV Adult and Adolescent Opportunistic Infection.. Autoimmune Retinopathy in Systemic Lupus Erythematosus.. JC virus A short history. The John Cunningham JC virus is a typically harmless polyomavirus carried by most humans. The virus was named after the patient in whom it was first identified in 1971. All age groups are susceptible to the virus, but elderly patients with comorbidities are more likely to experience severe illness. The mean age of hospitalized patients in an early reports was 59 years old, with a predominance of male patients 56%. The mean incubation time has been reported as 4.1 to 7 days. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.