Chloroquine intercalation

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  1. Belkin Well-Known Member

    Chloroquine intercalation


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Apr 02, 2019 Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Another convincing argument that chloroquine acts by intercalation was made by O'Brien and Hahn6. These authors made models of chloroquine and DNA the old-fashioned hand-made type, and proposed that chloroquine bound to DNA in two ways Fig. 2. First, the aromatic quinotine rings stacked between adjacent base pairs like other intercalators. Chloroquine as Intercalator a Hypothesis Revived S. R. Meshnick The mode of action of chloroquine is still controversial. Proposed mechanisms of action include I DNA intercalation, 2 lysosome accumulation and 3 binding to ferriprotoporphyrin IX. Recent data sug- gest that intercalation into parasite DNA

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine intercalation

    Positive Supercoiling of Mitotic DNA Drives Decatenation., Chloroquine as intercalator a hypothesis revived.

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  7. It has been suggested that chloroquine may augment oxidative stress induced by radiotherapy in the treatment of GBM. 6 The other main actions of chloroquine responsible for most intracellular actions are 1 molecular intercalation of chloroquine into DNA and 2 inhibition of lysosomic enzymes, particularly phospholipase A2.

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    Unwinding of the double strands of the DNA helix is a hallmark feature of intercalating drugs, such as chloroquine, ethidium bromide and m-AMSA. As part of characterization of novel agents, it is often important to know whether a novel compound is a DNA intercalator. Effects of chloroquine on the torsional dynamics and rigidities of linear and supercoiled DNAs at low ionic strength. Biopolymers 1989, 28 10, 1695-1703. DOI 10.1002/bip.360281005. J. Michael Schurr, Bryant S. Fujimoto, Pengguang Wu, Lu Song. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.

     
  8. antonr1982 Guest

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. RCOphth guideline Hydroxychloroquine and Chloroquine. Hydroxychloroquine and Chloroquine Retinopathy - Download. Aralen chloroquine Malaria Drug Side Effects & Dosage
     
  9. Banju Well-Known Member

    Hydroxychloroquine HCQ TRIALNET Type 1 Diabetes TrialNet Within 3 months of starting the study drug, you will also need to undergo a study-specific eye exam performed by an optometrist or ophthalmologist. Your study site will inform you where to go to have the eye exams completed at no cost to you. Study visit 3. At the 6-month visit, in addition to blood tests and monitoring, you will undergo an OGTT.

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