Listing a study does not mean it has been evaluated by the U. Hydroxychloroquine, which blocks autophagy, may slow the growth of and possibly kill prostate cancer cells. This phase II trial studies how well hydroxychloroquine works in treating patients with previously treated prostate cancer. How long does plaquenil take to work for ra Aralen malaria prevention Hydroxychloroquine dile Summary. Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, and inhibition of autophagy by chloroquine may sensitize not only cancer cells, but also normal organs to chemotherapy. Chemotherapy causes a variety of acute and chronic. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. found that chloroquine suppressed the growth and metastasis of melanoma by acting on tumor. Once cohort A completed, the dose of hydroxychloroquine will then be increased to 600mg per day (200mg three times per day)(cohort B). Hydroxychloroquine will be taken at a dose of 200 mg twice per day in the first 27 patients (cohort A). Chloroquine prostate cancer Chloroquine Oral Uses, Side Effects, Interactions., Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy Side affects hydroxychloroquineChloroquine synthesis mechanism The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. NCI Drug Dictionary - National Cancer Institute. Where and How Chloroquine Fights Cancer Science Signaling. Chloroquine and hydroxychloroquine for cancer therapy. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects.