Plaquenil in treatment of porphyria

Discussion in 'Hydroxychloroquine 200 Mg Tablet' started by LinksPro, 22-Feb-2020.

  1. zealot Moderator

    Plaquenil in treatment of porphyria


    High doses of glucose can inhibit heme synthesis and are useful for treatment of mild attacks. United Kingdom guidelines recommend administering 5% glucose in 0.9% sodium chloride solution, infused intravenously at a rate of 2 L/24 h.

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    Before using Plaquenil, tell your doctor if you are allergic to any drugs, or if you have psoriasis, porphyria, liver disease, alcoholism, or glucose-6-phosphate dehydrogenase G-6-PD deficiency. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. Plaquenil is included in the World Health Organization’s List of Essential Medicines, a listing of the essential medications needed in a basic health system. 8 The drug, in its generic form, is cheap and generally well tolerated. It does not require regular laboratory monitoring. Acute intermittent porphyria AIP is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.

    Patients experiencing severe attacks, especially those with severe neurologic symptoms, should be treated with hematin in a dose of 4 mg/kg/d for 4 days. Intravenous glucose in water solutions (eg, dextrose 5% or 10% [D5W, D10W]), should be avoided as they may aggravate hyponatremia.

    Plaquenil in treatment of porphyria

    Hydroxychloroquine - Wikipedia, Plaquenil From Malaria Treatment to Managing Lupus, RA.

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    • Porphyria - Diagnosis and treatment - Mayo Clinic.
    • Acute Intermittent Porphyria Treatment & Management..
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    The beneficial effects of Plaquenil on lipid profiles have been confirmed in numerous trials. 10-12 These effects are relatively small, with decreased LDL and triglycerides, but in RA and SLE, any medication that can partially mitigate the unfavorable lipid profiles of patients often on corticosteroids is not insignificant. Porphyria cutanea tarda PCT is an iron-related disorder that responds to treatment by phlebotomy or low-dose hydroxychloroquine, but comparative data on these treatments are limited. The hypothesis is that hydroxychloroquine is noninferior to phlebotomy in terms of time to remission. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

     
  6. kvt User

    If you have rheumatoid arthritis (RA), symptoms like joint pain and swelling are a given. Things that Changed My Life with Lupus Fatigue, Part 3 Chronic Fatigue From RA 6 Ways to Fight Back Everyday. Patient Information on Lupus Fatigue HSS Rheumatology
     
  7. publict Guest

    Rheumatoid Arthritis Treatment Options Johns Hopkins. Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Chloroquine is another antimalarial agent that is also sometimes used.

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria