Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Plaquenil and steroids Chloroquine effect on lysosomes Chloroquine for lupus Systematic review of the extent of chloroquine resistant P. vivax and the different methodologies used to quantify therapeutic efficacy Background One of the major threats to malaria control and elimination efforts is the ongoing spread and emergence of resistance towards commonly used antimalarial drugs to treat P. falciparum and P. vivax. Current status of drug-resistant malaria 10 3. Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13 USES Chemoprophylaxis Proguanil safe in pregnancy, give Folic acid Treatment of chloroquine resistant P.falciparum Malaria. Combinations Pyrimethamine & Dapsone-1 st line Pyrimethamine 25 mg & Sulfadoxine 500 mg Fansidar Mefloquine, Pyrimethamine & Sulfadoxine Fansimef Artesunate in combination Sulfadoxime & Pyrimethamine. Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine. Chloroquine resistant malaria ppt Treatment of Malaria – Malaria Site, Drug resistance in malaria Describe eye tests for plaquenilPsoriasis hydroxychloroquine There are only a few places left in the world where. chloroquine is still effective including parts of Central America and the Caribbean. CDC keeps track of all the places in the world where malaria transmission occurs and which malaria. drugs that are recommended for use in each place. Medicines for the Prevention of Malaria While Traveling.. Antimalarials authorSTREAM. Drug Resistance in the Malaria-Endemic World. Chloroquine With primaquine. Treatment of malaria To treat Malaria we most understand 2 concept • The geographic pattern of susceptibility of P. Falciparum to antimalarial drugs. • The type of plasmodium species causing the infection. Chloroquine- sensetive areas Chloroquine -resistant areas Chloroquine. 18. Malaria Prophylaxis Travel Medicine Bryan S. Delage MD MC FS SAS North Dakota Air National Guard RSV Training for FS 2013 Malaria Prophylaxis Objectives 1. – A free PowerPoint PPT presentation displayed as a Flash slide show on - id 502e31-ODY2N Schizonticide such as in areas with quinine quinine. resistance and/or Doxy 100 mg/kg Doxy 2 mg/kg reduce likelihood of 2 times per day for twice per day quinine-associated 7 days. for 7 days. side-effects by reducing duration of Prophylaxis 100 mg Prophylaxis 2 mg/kg quinine treatment. doxy per day.