Malarial chloroquine resistance

Discussion in 'Hydroxychloroquine 200mg' started by Natae, 14-Mar-2020.

  1. alexvy Moderator

    Malarial chloroquine resistance


    Plasmodium species are transmitted by the bite of an infective female mosquito. Occasionally, transmission occurs by blood transfusion, organ transplantation, needle sharing, nosocomially, or from mother to fetus.

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    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s. Chloroquine needs to be taken 1-2 weeks before traveling to an area with malaria, compared to some alternatives that can be taken 1-2 days before. chloroquine is only effective against malaria from certain areas of the world. chloroquine may worsen psoriasis, seizures, hearing problems, and liver conditions. Current status of drug-resistant malaria 10 3. Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13

    Travelers going to malaria-endemic countries are at risk for contracting the disease, and almost all of the approximately 1,700 cases per year of malaria in the United States are imported. Malaria is a major international public health problem; 91 countries reported an estimated 216 million infections and 445,000 deaths in 2016, according to the World Health Organization (WHO) World Malaria Report 2017.

    Malarial chloroquine resistance

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  6. Uses. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then.

    • Chloroquine Phosphate - WebMD.
    • Drug resistance in malaria - World Health Organization.
    • History of antimalarials Medicines for Malaria Venture.

    Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct. The WorldWide Antimalarial Resistance Network WWARN is a collaborative platform generating innovative resources and reliable evidence to inform the malaria community on the factors affecting the efficacy of antimalarial medicines. Emergence of resistance to antimalarial drugs has become a major hurdle in the successful treatment of the infection, and has contributed significantly to global malaria-related mortality.1 Till date, drug resistance has been documented in P. falciparum, P. vivax, and P. malariae.1

     
  7. alpina69 Guest

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Question About Plaquenil Want to know good stuff about plaquenil - HealthBoards Viagra and other erectile dysfunction drugs Understand how.
     
  8. Koshhka Well-Known Member

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