Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Stopping plaquenil effects Plaquenil treatment for scleroderma Apr 20, 2011 Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. In patients weighing less than 135 lbs. it may require the gentle counsel of the eye doctor to bring this potentially touchy issue to the prescribing doctor's attention. Just as many eye doctors still use timolol 0.5% bid, so too do many rheumatologists continue to prescribe Plaquenil at 200mg bid—regardless of the patient's lean body weight. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Eye test for plaquenil toxicity frequency Plaquenil Side Effects on Your Eyes and Vision, Plaquenil Updates eyeupdate Medicine plaquenil 200 mgChloroquine fish foodPlaquenil toxicity in the eyePlaquenil helped migairnesChloroquine in amoebic liver abscess Plaquenil is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. Plaquenil is indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported. Limitations of Use in Malaria • Plaquenil is not recommended for the treatment of complicated malaria. Plaquenil - FDA prescribing information, side effects and uses. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil and eye exams" Lupus Community - Support Group. Hydroxychloroquine Why you need an eye exam March 09, 2017 / Stonewire Optometry / Stonewire Optometry Hydroxychloroquine Plaquenil was originally a medication used to help prevent and treat malaria but was later discovered to have positive effects on autoimmune conditions as well. The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. It is not advised and/or is no longer standard of care to order fundus photos, time-domain OCT, FA, full-field ERG, Amsler grids, color vision testing, or electrooculography EOG to screen for Plaquenil toxicity. Some of these tests can show photoreceptor damage, but only in the late stages of the disease.