Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Malarone versus chloroquine Plaquenil stomach upset Plaquenil is what they prescribe for Lupus, Sjogren's and mild RA, so even though we aren't given the official diagnosis, we are treated the exact same. Plaquenil has been amazing for me. It does take about 3 months to notice. I was sensitive to the sun before I started, I'm not sure if this has improved because I avoid the sun completely. If you have lupus, protecting yourself from sun exposure is an essential part of managing your people with lupus experience photosensitivity or unusual sensitivity to sunlight. This. I stopped taking the Plaquenil several months ago and no longer have this reaction in the sun. If you feel okay in the sun, I would suggest slathering on the sunscreen, put on a hat and soak it in! If it makes you feel good and you are being careful, that's all that matters! Have a nice trip. Wendy Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and being in the sun Sun Exposure and Lupus Everyday Health, Lupus and Sun Exposure Plaquenil allergic rash does it burn If you are allergic to hydroxychloroquine; any part of hydroxychloroquine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have had any eye changes or changes in eyesight due to hydroxychloroquine or drugs like this one. If you have psoriasis. If you have porphyria. Hydroxychloroquine Indications, Side Effects, Warnings -. Plaquenil and the sun - Sarcoidosis - Inspire. Hydroxychloroquine Indications, Side Effects, Warnings.. A lot of people have less than 4, or as in my case, more than 4 but spread out over much more than 5 years. So it's very possible for plaquenil to do good without you being considered to have Lupus. I went on plaquenil in 2004 for joint pain, high ANA and pericarditis. Photosensitivity reaction is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months, also take medication Humira, and have Pain Photosensitivity is a common side-effect of methotrexate, plaquenil, and NSAIDs such as celebrex or advil. Photosensitivity may also be a serious side-effect of anti-TNF drugs such as cimzia, enbrel, humira, remicade, and simponi, as well as sulfasalazine.