I started on it just less than 2 weeks ago, and I'm surrounded by ill people at work and already have a bit of a cold (nothing severe). it is "milder" than a lot of the other dmards in terms of side effects and activity x It is listed as having a mild immunosuppressant effect in my book on RA, but one of the reasons for the blood tests is to check that your immune system is not being suppressed too much (eg checking your white blood cell levels), so you shouldn't be completely vulnerable. Even after several years of taking lots of drugs I've not found any difference in the number of colds etc I get, and loads of people on here are teachers etc who get a lot of exposure to colds and coughs without too much problem. Medicine reactions between plaquenil and xolair Chloroquine and proguanil brand Aug 25, 2011 I'm not a healthcare provider, but I do take Plaquenil and just found out from another user of it that it does suppress the immune system. I didn't know that when I started taking it for Sjogren's in November 2011. In January 2012, I had a horrible cold, stomach flu and then SHINGLES. It alters your immune system, but as far as I know, it doesn't actually suppress it. Plus, if you have only been on it a month, it's probably not built up enough in your body to have much of an effect. I have actually been way HEALTHIER than ever since being on Plaquenil AND Methotrexate, which DOES suppress the immune system - go figure! Higher doses of medications that weaken your immune system are more likely to increase your risk of getting a fungal infection. 5,11,13,14. Click on the sections below to see lists of corticosteroids and TNF inhibitors that can increase the chances of getting a fungal infection. Polly Thank you both, I thought it shouldn't be too bad and that it's pretty mild in comparison to other drugs. Always better to be well informed and I remember the consultant saying its bit a bad time of year to start on it as I've missed all the bugs round Christmas time so thought there may be a slim chance of it being suppressed. But do look after yourself, and make sure you eat well and don't get too tired as if you have a cold already you need to pamper yourself a bit more than you would have before RA. Does plaquenil lower immune system Plaquenil and its affect on the immune system DailyStrength, Does Plaquenil supress the immune system? Plaquenil prednisonePlaquenil and ra Mar 23, 2014 I doubt it is the Plaquenil affecting your immune system, but the actual Lupus itself as it can affects the white blood cells and lower them so we get every infection going. You need to speak to your rheumy for more clarification in your case. Plaquenil and immune system Lupus Forums at The Lupus Site. Medications that Weaken Your Immune System and Fungal.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Aug 02, 2010 All work by suppressing the immune system. If he wants this type of drug he can try to balance control of his autoimmune disease with the risk of infection. What I mean is He might want to consider taking a lower dose of Plaquenil. This won't suppress his immune system quite as much but it also won't completely control his Sjogrens. I started on plaquenil about 3-4 yrs ago and now the last two yrs I've gotten sick several times. They use plaquenil to suppress your immune system to slow it down, not speed it up. Your system is working overtime, so IMO, its stronger and that causes the problems we have the body needs a nice nuetral immune system working normally. Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. This is the case with everyone I know that takes it. My rheumy has saidand everything I've read on Plaquenil that Plaquenil NEEDS that amount of time to build in your system before it stats to have beneficial.