It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. I had almost (but not quite) forgotten what these aches and pains feel like, but they're back…I am re-acquainting myself with those symptoms that it tames: the overall flu-like and feverish feeling -- aka malaise -- and joint pain." (Click here to read more). I had a similar experience when I stopped taking plaquenil. Plaquenil for scleroderma Plaquenil pregnancy aps Chloroquine Aralen This drug has been known to have more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Quinacrine Atabrine Quinacrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. Hydroxychloroquine Plaquenil, a drug designed to treat malaria, is often helpful in treating Sjogren's syndrome. Drugs that suppress the immune system, such as methotrexate Trexall, also might be prescribed. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. My joint and muscle pain went up and my energy levels went down. No, but it did alleviate some of the symptoms and improve my quality of life. It was one of those situations where I didn't realize the medication was having such an impact until I stopped it. Hydroxychloroquine for sjogren's syndrome vs another drug Sjogren's Hydroxychloroquine No Better Than Placebo, Sjogren's syndrome - Diagnosis and treatment - Mayo Clinic What does plaquenil do for raPlaquenil and feeling sickPregnancy ssa hydroxychloroquineEyes hydroxychloroquineSafe to take plaquenil with antacids Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Reduces inflammation and cell replication. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Compare Plaquenil vs Methotrexate -. Hydroxychloroquine - Wikipedia. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Hydroxychloroquine belongs to the family of medicines called “antimalarials” AMs, which are also classified as disease-modifying anti-rheumatic drugs, or DMARDs. These drugs were initially used to prevent and to treat malaria but are no longer used for those purposes; more effective drugs have since been developed. Hydroxychloroquine generic Plaquenil is often prescribed off-label by doctors for Sjogren’s Syndrome patients despite the fact that it has never been approved by governing agencies like the FDA. I myself have taken hydroxychloroquine for several years. My understanding is that the rheumatologist thinks that plaquenil is synergistic with mycophenolate and the 2 have a better chance of halting the progression of the neuropathy, and the other current and possible impacts of Sjogren’s better than mycophenolate alone.