Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil vulvar lichen planus Hydroxychloroquine sulfate pregnancy Chloroquine for hpv Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Aug 08, 2018 This relative thinning of outer retinas was caused by a thinning of two specific portions of the outer retina the outer nuclear layer ONL and ellipsoid zone EZ. The outer nuclear layer or layer of outer granules or external nuclear layer, is one of the layers of the vertebrate retina, the light-detecting portion of the eye. Like the inner nuclear layer, the outer nuclear layer contains several strata of oval nuclear bodies; they are of two kinds, viz. rod and cone granules, so named on account of. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil and thinning outer nuclear layer of retina Automated Segmentation Measurements of the Outer Nuclear., Eye Exam May Aid Diagnosis of Frontotemporal Dementia Plaquenil and hair colorHydroxychloroquine nhs The inner retinal layers are significantly thicker and hyperreflective from the acute infaract. After the initial acute phase of the retina artery occlusion, the swollen inner retinal layers will start to atrophy. OCT scans will display thin inner retinal layers with fairly normal outer retinal layers. Retinal Vascular Diseases - Optical Coherence Tomography Scans. Outer nuclear layer - Wikipedia. Photoreceptor outer nuclear layer thickness changes in optic.. Outer nuclear layer ONL thinning was present in 100 % and observed as a focal indentation in the parafoveal ONL when compared to peripheral ONL thickness. Disruption of the parafoveal interdigitation zone IZ was recorded in 88 % and reduced reflectivity of the parafoveal EZ band in the absence of definitive disruption was observed in 50 %. Spectral-domain optical coherence tomography demonstrating advanced hydroxychloroquine retinopathy with parafoveal loss of the external limiting membrane, disruption of the outer ellipsoid zone, thinning of the outer nuclear layer and disruption to the underlying retinal pigment epithelial layer A. The choroidal vasculature supplies the outer one-third of the inner nuclear layer, outer plexiform layer, outer nuclear layer, photoreceptors, and RPE. Because of this division of the blood supply to the retina, ischemic choroidal vascular lesions and ischemic lesions attributed to the retinal vasculature produce different histologic pictures.