Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Plaquenil and celexa interaction Hydroxychloroquine 200 mg tablet cost Severe Interactions These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in formation. These medications may interact and cause very harmful effects. Consult your healthcare professional e.g. doctor or pharmacist for more in formation. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Can I still take vitamin supplements while on methotrexate? Q I take plaquenil and methotrexate for my rheumatoid arthritis, and folic acid. My rheumatology clinic has suggested not taking vitamin supplements as it's not known if they'll react with methotrexate and stop it working. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Can i take plaquenil and methotrexate together Which would you pick and why? - Plaquenil or Methotrexate, Plaquenil hydroxychloroquine sulfate dose, indications. Plaquenil testing aao Methotrexate and plaquenil. now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. i am still in so much pain everyday and hoping for some relieve soon. Methotrexate and plaquenil -. Your questions on alternative supplements. Methotrexate vs Plaquenil Comparison -. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Summary Drug interactions are reported among people who take Methotrexate and Plaquenil together. This study is created by eHealthMe based on reports of 23,242 people who take Methotrexate and Plaquenil from Food and Drug Administration FDA, and is updated regularly. I am on Methotrexate and plaquenil, that help with the aches and pains. I also take 3 mgs of melatonin just before bed which helps so much, it may take a week or so before it is truly effective, I still wake early about 5 am but have learned to just lay and relax till time to get up.