She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Can plaquenil cause hair loss Can i take hydroxychloroquine while pregnant Interactions with plaquenil and fluconazole Chloroquine-induced pigmentation Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. Risk Factors. There are risk factors which may increase the likelihood of an individual in developing symptoms of Plaquenil toxicity 1. Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Findings on eye examination include the following Corneal deposits. Posterior subcapsular lens opacity chloroquine. Irregularity in the macular pigmentation and blunting of the foveal reflex early. Bull’s eye maculopathy classic finding in non-Asian patients. Peripheral pigment. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Chloroquine maculopathy Chloroquine Side Effects Common, Severe, Long Term -, Hydroxychloroquine toxicity - EyeWiki Is doxycycline and plaquenil similar drugsQuinacrine with hydroxychloroquine A Fluorescein angiogram of a patient with perifoveal atrophy of the pigment epithelium corresponding to a bull's eye maculopathy, typical of chloroquine retinopathy. B Central retinal sensitivities Octopus program 11 at 3° spacing show depression superiorly and temporally, corresponding to areas of fluorescein angiogram with more marked. Maculopathy - an overview ScienceDirect Topics. Chloroquine and Hydroxychloroquine Toxicity Practice.. Hydroxychloroquine Retinopathy Still Alive and Well - The.. Chloroquine Retinopathy Rheumatic Disease. Alastair K. Denniston. Ocular complications of rheumatological therapies may relate. Autofluorescence Imaging. Monika Fleckenstein. FAF imaging may show distinct alterations due. MEDICAL RETINA. Age-related macular degeneration AMD is a. Applies to chloroquine compounding powder, injectable solution, oral tablet. Ocular. Maculopathy and macular degeneration may be irreversible. Irreversible retinal damage has been reported in patients receiving long-term or high-dose 4-aminoquinoline therapy. Retinopathy has been reported as dose related. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Hydroxychloroquine is used widely for the treatment of systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatologic conditions.