One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Alternativesto taking plaquenil Leukemia and plaquenil Plaquenil lyme joint pain How long before itching stop after stopping plaquenil Table 3 demonstrates that fields, mfERG, FAF, and SD-OCT can all show damage at a relatively early stage of hydroxychloroquine toxicity, but it is not predicable as to which test will be most definitive for any given individual. This makes a strong argument for using more than 1 modality routinely or at least for bringing in multiple modalities. Revised Recommendations on Screening for Plaquenil Toxicity • SD-OCT can show localized thinning of the parafovealretinal layers confirming toxicity – May be unable to see with TD-OCT – Changes maybe visible prior to VF defects • FAF may reveal subtle RPE defects with reduced autofluorescence • MF-ERG can objectively document localized. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Sd-oct and plaquenil toxicity Retinal Physician - Hydroxychloroquine Maculopathy An., Optical Coherence Tomography OCT The Origins of the OCT Plaquenil difficulty sleepingHydroxychloroquine pn singlecareDo you need a baseline eye exam before taking hydroxychloroquineHydroxychloroquine what is a good dosePlaquenil 200 mg uses SD-OCT showed loss of the parafoveal inner/outer segment junction, thinning of the parafoveal outer nuclear layer, and a loss of the normal foveal depression, which is characteristic for hydroxychloroquine retinal toxicity Figure 3. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Plaquenil Side Effects Common, Severe, Long Term -. Expanded spectral domain-OCT findings in the early.. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. *SD OCT Spectral Domain Optical Coherence Tomography. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Because early toxicity changes can be revealed on SD-OCT, it is prudent to perform a baseline screening of patients taking Plaquenil. Multifocal ERG has the ability to detect early macular dysfunction, so it should be included as part of baseline screening.