She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Dayquil drug interactions hydroxychloroquine Chloroquine blood plasma ratio Plaquenil and face rash Symptoms. Over time, Plaquenil can accumulate in the retina and cause permanent irreversible damage to the center of vision. The classic retinal changes appear as a “bull’s eye” area of discoloration of the central part of the retina. Symptoms of Plaquenil toxicity are similar to other macular problems and may include After six weeks on Hydroxychloroquine he got hundreds of black floaters in his eye, with intermittent flashes of light. We went to Addenbrooke's Hospital Casualty where the Casualty Doctor felt he'd had a retinal bleed due to the drug and were referred to the Eye Clinic as an emergency. The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience permanent vision loss resulting from hydroxychloroquine retinopathy due to improper dosing of the drug and improper screening. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Symptoms of retinal damage from plaquenil Plaquenil Hydroxychloroquine Side effects, Images, Uses, Dosage., Hydroxychloroquine causing retinal damage My husband. - NRAS Chloroquine stockThe mainstay of treatment for malaria is chloroquine My last retina scan shows some thinning of the retina so I am being scheduled with a specialist for further testing and I have been told there is a good possibility I will have to stop taking Plaquenil. I know my sight is most important but it makes me nervous that I may have to change medications. Plaquenil has been a miracle drug for me. Has anyone had retinal damage from Plaquenil? - Lupus - Inspire. Despite Plaquenil dosing recommendations, retinal toxicity remains. Plaquenil oral Reviews and User Ratings Effectiveness, Ease of Use.. However, most patients usually notice symptoms only after scotomas have become severe. When allowed to advance, hydroxychloroquine retinal toxicity leads to loss of up to three visual functions acuity, peripheral vision and night vision. Signs. Feb 19, 2020 Tell your doctor if you experience serious side effects of Plaquenil including. muscle weakness, twitching, uncontrolled movement, loss of balance or coordination, blurred vision, light sensitivity, seeing halos around lights, Over time, hydroxychloroquine may uncommonly have an adverse effect on the retina that can lead to permanent visual damage if not picked up early. In order to protect the eyes, a baseline exam is recommended be- fore starting the drug if you are color blind, have prior retinal problems or have never had a dilated exam checking color vision is.